Prof. Prashantha C N Assistant Professor

Specialization

Areas Of Interest

Genomics, Pharmacogenetics, Metagenomics, Drug Discovery, Proteomics, Biostatistics

Programs Organised

Qualification

M.Sc (Biochem), M.Sc. (Bioinfo)., PhD

Teaching Experience

5 Teaching + 10 Industry

Vidwan ID/Profile URL

Scopus ID/Google Scholar ID

Funded Project (amount sanctioned)

• 265000 Lakh (Seed Fund) REVA University

Publications In Refereed Journals

Key Publications (Only Q1 & Q2 Rated)

• Design, synthesis, and molecular docking studies of some 1-(5-(2-fluoro-5-(trifluoromethoxy) phenyl)-1,2,4-oxadiazol-3-yl) piperazine derivatives as potential anti-inflammatory agents. B Kulkarni, K Manjunatha, Nibin Joy, Sajith, CN Prashantha, Ranjith P, Mohammed B A; Molecular Diversity, 1-13, 2021.
• RNA Sequencing-based Transcriptomic profiles of HeLa, MCF-7 and A549 cancer cell lines treated with Calotropis gigantea leaf extracts; Bindu Damodaran, B Prabhu, G Vinoth Kumar, CN Prashantha, Swetha Reddy Pulakuntla, GM Sankolli, P Venkataraman; Gene Reports, 23, 101119, 2021.
• Atranorin, an antimicrobial metabolite from lichen Parmotrema rampoddense exhibited in vitro anti-breast cancer activity through interaction with Akt activity; Adhikesavan Harikrishnan, V Veena, B Lakshmi, R Shanmugavalli, Sonia Theres, CN Prashantha, Tanya Shah, K Oshin, Ringu Togam, Sisir Nandi.Journal of Biomolecular Structure and Dynamics; 39(4);1248-1258, 2021.
• Molecular screening of antimalarial, antiviral, anti-inflammatory and HIV protease inhibitors against spike glycoprotein of coronavirus; CN Prashantha, K Gouthami, L Lavanya, Sivaramireddy Bhavanam, Ajay Jakhar, RG Shakthiraju, V Suraj, KV Sahana, HS Sujana, NM Guruprasad, R Ramachandra; Journal of Molecular Graphics and Modelling; 102; 107769; 2021.
• Molecular Modelling and Insilico Engineering of PapMV-CP Towards Display and Development of Capripox Viral Like Particles Based on Immunogenic P32 Envelop Protein is the Homologous of the Vaccinia-Viral H3L Gene: An Insilico Approach; C. N. Prashantha Burranboina Kiran Kumar, K. M. Kumar, G. B. Manjunatha Reddy, Sunil Abraham, R. Yogisharadhya; International Journal of Peptide Research and Therapeutics; 26; 2155–2167;2020.
• Phytochemical screening and evaluation of cytotoxic activity of Calotropis gigantea leaf extract on MCF7, HeLa, and A549 cancer cell lines; Bindu Damodaran, Prashantha Nagaraja, Vivek Jain, MP Manuja Viraj Wimalasiri, GM Sankolli, G Vinoth Kumar, Venkataraman Prabhu; Journal of Natural Science, Biology and Medicine; 10(2); 131; 2019.
• Extract from Butea monosperma inhibits β-catenin/Tcf signaling in SW480 human colon cancer cells; Navaneethakrishnan Polachi, Boopathi Subramaniyan, Prashantha Nagaraja, Kannan Rangiah, Mathan Ganeshan; Gene Reports; 10; 79-89, 2018.
• Synthesis and in vitro cytotoxicity study of 3-(1 H-indol-3-yl)-1, 3-diphenylpropan-1-ones; Jagadeesh N Masagalli, Kittappa M Mahadevan, Honnali Jayadevappa, Hosanagara N Harishkumar, Rajesha Ganalu, Prashantha Nagaraja; Medicinal Chemistry Research; 23 (6); 2880-2889; 2014.

Other Publications

• Identification, and In-silico Prediction of Hermetia illucens Larval Protein that Inhibits the Progression of Cervical Cancer.; Nisha Rajasekhar, Ramesh N, Prashantha C.N. International Journal of Engineering and Advanced Technology (IJEAT), ISSN: 2249 – 8958, Volume-9 Issue-3, February 2020.
• Isolation and Characterization of Hermetia Illucens Larval Protein for the Assessment of Inhibitory Activity against MCF7 and HeLa cell Lines.; Prashantha C.N, Nisha Rajasekhar, Ramesh. N. International Journal of Innovative Technology and Exploring Engineering (IJITEE). 2020. Volume 9, Issue 3, Pages 3045-3050.
• In Silico Analysis of Active Constituents of Silymarin as Alpha-Glucosidase Enzyme Inhibitors in Type 2 Diabetes Mellitus; Ahmad Zenobia, Prashantha CN, D Visaga Perunal, Zahra Mafibaniasadi. Asian Journal of Pharmaceutical and Clinical Research. 2019 12(9), 225-229.
• Virtual Screening of Bio-active Compounds as an Inhibitor of c-FLIP Protein for Cancer Treatment; Prashantha Nagaraja, Arighni Guhathakurta, Shweta Sukla Baidya and Pujitha Krishnasamudram. Conference on Drug Design and Discovery Technologies, 2019, p21-24 Royal Society of Chemistry.
• Differentially expressed neurogenin-3 gene in neuronal cell development of pancreatic cell; Prashantha Nagaraja, Sonika Rai, Alivia Saha, Ragini V Murthy, Ramachandra R.  National Conference on Computational World in Life Sciences, Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Sciences, 2019, 5(2), 282-294.
• The identification and validation of differentially expressed genes of both mouth buccal cavity and nasal cavity epithelial tissues of lung cancer; Kiran Raj T Akash Dnyanoba Adude, Rahul Dnyanoda Chandawar, Gajanan Balaji Gaikwad, Prashantha Nagaraja. National Conference on Computational World in Life Sciences, Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Sciences, 2019, 5(2), 208-218.
• Computational approaches and molecular docking of target natural chemicals for target as glutathione-stransferase; R. Ramachandra Swetha Sukla, Padmaja, Arghni, Prashantha C N, Guruprasad NM. National Conference on Computational World in Life Sciences, Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Sciences, 2019, 5(2), 200-207.
• Peptidomimetics: structural and pharmacological identification of novel peptide of target chymase enzyme activity to predict asthma treatment; Nisha Rajasekhar, Asiya Rozinder, D.B.M. Virupakshaiah, Prashantha C.N. National Conference on Computational World in Life Sciences, Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Sciences, 2019, 5(2), 185-199.
• Pharmacogenomics approach as personalized medicine for type 2 diabetes mellitus; Prashantha C.N, Gouthami K, Veeraraghavan V, Vani Puttaraju, Ramachandra R. National Conference on Computational World in Life Sciences, Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Sciences, 2019, 5(2), 19-37.
• Transcriptome analysis to identify disease resistance genes through novel next generation sequencing applications for the predictive medicine. Prashantha C, N. Journal of Applied Bioinformatics & Computational Biology. 2019 (8).
• The Case of Efficient Animal Models for Regenerative Medicine: A Computational Investigation; Dhanya V. Menon, *Darshan Patel, Prashanth Nagaraja, Chaitanya G. Joshi. Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Sciences. 2019. 5(2), 282-294.
• Exploration of Novel Sulpho Tyrosine Based Unnatural Amino Acid Ligand for Inhibition of Human Shp2, A Computational Approach. Raja Ganapathy Kaliyaperumal, Manjunatha Panduranga Mudugal, Prashantha Nagaraja, Nageena Taj. Journal of Drug Design and Medicinal Chemistry. Vol. 4, No. 3, 2018, pp. 22-34.
• Microarray Meta-Analysis of BRCA1 Mutated Genes Involved in Breast Cancer; Sukanya, V.K., Nagaraja, P., Manokaran, S., Hanumanthareddy, A. Reddy, M. and Surana, P. (2018) Open Access Library Journal, 5: e5000.
• Whole Exome Sequence Analysis to Predict Functional Biomarkers for Pancreatic Cancer. C.N.Prashantha, Maheswari L Patil, Shivakumar B Madagi. International Journal of Advanced Research in Computer Science, 2018, 9(3), 361-367.
• Enabling rapid and efficient selection of Next generation sequencing algorithms to align sequences to predict differentially expressed genes in cancer.  C.N. Prashantha, Maheswari L Patil, Shivakumar B Madagi. Canadian Journal of Biotechnology, 2017, 1, 22.
• Transcriptome Analysis of m-RNA Expression Profiling To Predict Potential Biomarkers Induced In Breast Cancer-BRCA1. Reshma Jacob, Seema J Patel, Prashantha C N. Asian Journal of Pharmaceutical and Clinical Research, 2016, Vol. 9, no. 6, pp. 270-3.
• In silico analysis of inhibitor and substrate binding site of Serra peptidase from serratia marcescens MTCC 8708. Kaviyarasi, N.S. and Prashatha, C.N. and Suryanarayana, V.V.S. International Journal of Pharmacy and Pharmaceutical Sciences, 2016, 8 (4). pp. 123-128.
• Whole transcriptome cerebral cortex gene analysis in Alzheimer’s diseases; Pooja S., Muttagi A.P., Patel S.J., Gurumurthy H., and Prashantha C.N., Computational Molecular Biology, 2016, 6(2): 1-9.
• Meta-Analysis of Gene Expression Data of Multiple Cancer Types To Predict Biomarkers and Drug Targets Interactions in Ovarian Cancer, Shashank K.S., Mamatha H.R., and Prashantha C.N., Computational Molecular Biology, 2015, 5(5): 1-9.
• Gene Expression Profile of Ovarian Cancer Dataset that helps to Predict Potential Biomarkers. Divya, V., Anitha P. Muttagi, Seema J Patel, Gurumurthy, H. and Prashantha Nagaraja. International Journal of Current Research in Life Sciences. 2015, Vol.4, No.08, pp.321-327.
• Molecular Characterization of Salmonella SP1 Component Proteins Involved in Pathogenicity and is Used for Potential Drug Targets. Anuradha, Shilpa N, Shambu M G, Anitha P.M, Tanusree Bhattacharya, Prashantha Nagaraja, American journal of Pharmacy and Health Research, 2015, 3(4).
• Synthesis and Molecular Docking study of 2-Aryl/Heteroaryl quinoline - 4-Carboxylic Acids for Antimalarial, Antituberculosis and Anticancer Activities. P.S. Pradeep, T.O. Shrungesh Kumar, C.N. Prashantha, K.M. Mahadevan. International Journal of Chemical and Physical Sciences, 2015, 4(4), 74-92.
• Synthesis, in-vitro Antibacterial Toxicity and Molecular Docking Anticancer Activity of Novel N-[(2-Chloroquinolin-3-yl) methylidene]-2-aniline Schiff bases. P.S. Pradeep, T.O. Shrungesh Kumar, C.N. Prashantha, K.M. Mahadevan. International Journal of Current Pharmaceutical Research, 2015, Vol 7, Issue 3, 37-46.
• Antiproliferative Activity of N-Butanol Floral Extract from Butea Monosperma against HCT 116 Colon Cancer Cells; Drug Likeness Properties and In Silico Evaluation of Their Active Compounds toward Glycogen Synthase Kinase-3β/Axin and β -Catenin/T-Cell Factor-4 Protein Complex. Navaneethakrishnan Polachi, Prashantha Nagaraja, Boopathi Subramaniyan, Ganeshan Mathan. Asian Journal of Pharmacy and Clinical Research, 2015, Vol 8, Issue 1, 134-141.
• Toxicity and Molecular Docking Studies of Tetrahydroquinoline against Microbial, Cancer, Retinoic Acid Receptor, Inflammatory, Cholesterol Ester Transferases and Parasitic Protein Receptors. Pradeep P S, Kiran Kumar, H Chandrashekarappa, Jagadeesh N M, Prashantha Nagaraja, K M Mahadevan. International Journal of Pharmacy and Pharmaceutical Sciences, 2014, Vol 7, Issue 2, 448-459.
• Synthesis and molecular docking study of N-alkyl/aryl-2-aryl indol-3-yl glyoxylamides as novel anticancer agents. NM Jagadeesh, KM Mahadevan, MN Kumara, C N Prashantha. International Journal of Pharmacy and Pharmaceutical Science, 2014, Volume 6, Issue 2, Pages 921-926.
• In Silico Design of Butea monosperma Floral Derived Compounds and Its Inhibitory Effect on β-Catenin, GSK-3β and APC Complex Proteins in Colorectal Cancer; Navaneethakrishnan P, Prashantha C N, Boopathi S, Sabitha R, Mathan G. (2013) International Journal of Drug Discovery, 2013, Volume 5, Issue 1, pp.-191-197.
• Designing of Anti Dengue Drug Molecule against Insilico Modelled Target DC-Sign (CD-209). CN Prashantha, Arti Patil, Shanmuga Priya. International Journal of Advanced Computer Research, 2013, 3(3), 215-223.
• Analysis of gene expression on ngn3 gene signalling pathway in endocrine pancreatic cancer. Prashantha Nagaraja, Kavya Parashivamurthy, Nandini Sidnal, Siddappa Mali, Dakshyani Nagaraja, and Sivarami Reddy. Bioinformation, 2013, 9(14), 739–747.
• Analysis of Gene expression data using MATLAB Software; R Priscilla, Prashantha CN, S Swamynathan, International Journal of Artificial Intelligence and Computational Research 2010, 1(1), 51-56.

Research Summary

The aim of the research is to identify the personalized medicine for the human using genomic applications. My research is focused on whole genome sequencing, whole exome sequencing, resequencing, Transcriptome-Seq, Metagenomic sequencing, etc. I have done the whole transcriptome sequencing and analysis of Calotropis gigantea plant. Whole exome sequencing of Individual human population to predict the hereditary diseases and develop functional biomarkers and develop personalized medicine. I also focused on drug discovery based on synthetic compounds and phytochemicals to the specific target disease include cancer, viral diseases, Bacterial diseases, etc.

UG / PG Projects