School of Applied Sciences
Ph.D.
7 Years
Human metallo-β-lactamase enzymes degrade penicillin
Diene SM, Pinault L, Keshri V, Armstrong N, Khelaifia S, Chabrière E, Caetano-Anolles G, Colson P, La Scola B, Rolain JM, Pontarotti P, Raoult D. Sci Rep. 2019 Aug 21;9(1):12173. doi: 10.1038/s41598-019-48723-y. PMID: 31434986; PMCID: PMC6704141.
Promiscuous Enzyme Activity as a Driver of Allo and Iso Convergent Evolution, Lessons from the β-Lactamases
Keshri V, Chabrière E, Pinault L, Colson P, Diene SM, Rolain JM, Raoult D, Pontarotti P. Int J Mol Sci. 2020 Aug 29;21(17):6260. doi: 10.3390/ijms21176260. PMID: 32872436; PMCID: PMC7504333.
Dual RNase and β-lactamase Activity of a Single Enzyme Encoded in Archaea
Diene SM, Pinault L, Armstrong N, Azza S, Keshri V, Khelaifia S, Chabrière E, Caetano-Anolles G, Rolain JM, Pontarotti P, Raoult D. Life (Basel). 2020 Nov 14;10(11):280. doi: 10.3390/life10110280. PMID: 33202677; PMCID: PMC7697635.
Phylogenomic Analysis of β-Lactamase in Archaea and Bacteria Enables the Identification of Putative New Members.
Keshri V, Panda A, Levasseur A, Rolain JM, Pontarotti P, Raoult D. Genome Biol Evol. 2018 Apr 1;10(4):1106-1114. doi: 10.1093/gbe/evy028. PMID: 29672703; PMCID: PMC5905574.
The functional convergence of antibiotic resistance in β-lactamases is not conferred by a simple convergent substitution of amino acid.
Keshri V, Arbuckle K, Chabrol O, Rolain JM, Raoult D, Pontarotti P. Evol Appl. 2019 Jul 18;12(9):1812-1822. doi: 10.1111/eva.12835. PMID: 31548859; PMCID: PMC6752183.
An Integrative Database of β-Lactamase Enzymes: Sequences, Structures, Functions, and Phylogenetic Trees.
Keshri V, Diene SM, Estienne A, Dardaillon J, Chabrol O, Tichit L, Rolain JM, Raoult D, Pontarotti P. Antimicrob Agents Chemother. 2019 Apr 25;63(5):e02319-18. doi: 10.1128/AAC.02319-18. Print 2019 May. PMID: 30783007
Other Publications
Structure Prediction and Binding Site Analysis of Hepatotoxic Microcystin-LR Degrading MlrC-Like Protein
from Burkholderia sp. using Computational Approaches
Singh DP, Prabha R, Keshri V, and Abhilash PC
2016, Current Research in Bioinformatics
Genome subtraction for the identification of potential antimicrobial targets in Xanthomonas oryzae pv
oryzae PXO99A pathogenic to rice
Keshri V, Singh DP, Prabha R, Rai A, and Sharma AK. 2013, 3Biotech (Springer) [PMID: 28324466]
Bioinformatics data analysis- Antibiotic resistance beta-lactamase gene identification from different domain of life such as bacteria, archaea, eukaryotes along with metagenomes,