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Research in Biochemistry Program in India - REVA University
Research in Biochemistry

Research in Biochemistry

List of Guides & their expertise

Name Research Interests
Dr. M. Mani Biocontrol Technology(Research Interests)
Dr.Jayashree S. Anti-Inlammatory compounds
Dr. Veeraraghavan V. Cardiovascular Diseases
Dr. T. P. Charan Raj Organic compound synthesis
Jayasri P. Biochemistry(General)
Mr. Ramesh Kumar Kushwaha Plant Biochemistry

Core team of research

Name Research Interests
Dr. M. Mani Emeritus Scientist, Adjunct faculty, RU (Biocontrol Technology)
Dr. Jayashree S. Anti-inflammatory compounds
Dr. Veeraraghavan V Cardiovascular Diseases
Mr. T. P. Charan Raj Organic compound synthesis
Dr. U. V. Babu Head R&D, Himalaya Drugs
Dr. Senthil Duraiswamy Director, Pharma Geneca.

Research Facilities

  • HPLC (Shimadzu)
  • Merck-Millipore - Aqualix Water Purifier
  • Rotary Evaporators, Chiller & Vacuum pump (KNF)
  • Low temperature reactors (Huber)
  • Spectrophotometers
  • Gel documentation system from Biorad Laboratories, USA
  • Online and Offline computational Biology tools.

Research Grants

a. In House Funded Projects

In vivo studies on antioxidant activity of natural products on Diabetic Retinopathy induced Rats.

b. Funding Agencies:NRCLPI and QCI

Evaluation of Lead concentration in milk and milk products, Evaluation of Lead concentration in Milk, Water, Grass and Feeds & Fodders in Doddaballapura

c. In house Students Projects (Ongoing)
  • In vivo studies on inhibitory activity of natural products on Diabetic Retinopathy patients.
  • Influence of natural products on inflammation.
  • Quantification of secondary metabolites in Vitis vinifera extracts.
  • Invitro studies on Anticancerous properties.
  • Investigation of anti-cancer activity in Polyalthia cerasoides.
  • Protective role of M.Champaca on oxidative damage.
  • Anti-cholesterol properties of Calotropis gigantean.
  • Isolation of phenolic compounds from Vaccinium corymbosum to reduce the toxicity of acrylamide.
  • Microbial diversity in rural, urban and industrial areas.

Research Publications/Paper presentation/Upcoming Publications

  • Jayashree S, Chaithra C, Ranjitha S B (2019), Study of anti-inflammatory effect of Terminalia arjuna, Res J Life Sci Bioinform Pharm Chem Sci. 5:301-307.
  • Gouthami K, Veeraraghavan V, Vani Puttaraju, Prashantha CN, Ramachandra R (2019), Pharmacogenomic approach as personalized medicine for type 2 diabetes mellitus, Res J Life Sci Bioinform Pharm Chem Sci. 5:19-37.
  • Pooja R Karkera, Abhishek Jha, Anjali Singh (2019), Review on inhibitors for protease and polymerase protein of hepatitis c virus (hcv), Res J Life Sci Bioinform Pharm Chem Sci. 5:156-162
  • Ramesh Kumar Kushwaha, Varsha R, Nikhil Kalshetty, C.S.Vivek Babu (2019), Repurposing Essential Oil for Control of Phytopathogenic Fungi, Res J Life Sci Bioinform Pharm Chem Sci. 5:163-170.
  • Pooja R Karkera, Ravikumar Y S (2019), Computational Screening of Enantiomeric Lignans and Neolignans from Phyllanthus glaucus for Inhibition of Dengue Viral Protease and Hepatitis C Virus, Res J Life Sci Bioinform Pharm Chem Sci. 5:171-178.
  • Jayashree S, Shalini S, Likitha PM (2019), Influence of Cyperus rotundus on Diabetic complications through in vitro studies, Res J Life Sci Bioinform Pharm Chem Sci. 5:308-315.
  • Daisy K L, V Veeraraghavan (2019), “The variation in the glucose levels after a night shift to a casual day: a cross over trail in healthy volunteers”, Res J Life Sci Bioinform Pharm Chem Sci. 5:335-340.
  • Mahadev C Khetagoudar, Madhusudhan Reddy, Mahadev B. Chetti, V VeeraRaghavan (2019), Ultra-performance liquid chromatographic separation of major phenolic compounds and determination minerals and trace elements in commonly consumed wheat varieties, Res J Life Sci Bioinform Pharm Chem Sci. 5:364-374.
  • Lavanya L, Vadamalai Veeraraghavan, Renuka Srihari (2019), Evaluation the effect of antioxidant and antidiabetic property of herbal plant extract (A. indicum) on niddm., Res J Life Sci Bioinform Pharm Chem Sci. 5:375-388.
  • Charanraj TP, Poonam Kumari, Subham Saha (2019), Biochemical test disclose the bacterial diversity in lake water, Res J Life Sci Bioinform Pharm Chem Sci. 5:389-394.
  • Ramesh Kumar Kushwaha, Sridhar Gowda K L, Shashi Kumar B S, Vinay Kumar D N (2019), Extraction and estimation of secondary metabolites in the leaf of Ocimum sanctum, Res J Life Sci Bioinform Pharm Chem Sci. 5:395-401.
  • Deepa HN, Singh Anchala, Sreenidhi U, Jayashree.S (2019), In vitro Assessment of Anti-inflammatory Activity of Michelia champacaLeaf Extract in RAW 264.7 Cell Line, Res J Life Sci Bioinform Pharm Chem Sci. 5:402-410.
  • Jayasri.P, Rajesh Das, Tamosha Mitra, Debasmita Bhadury (2019), Qualitative analysis of phytochemical compounds from three types of raisins and determination of the
  • Quantity of gallic acid with the help of HPLC, Res J Life Sci Bioinform Pharm Chem Sci. 5:420-427.
  • V.Veeraraghavan, N.R.Neeraja (2019), HPLC analysis of blueberry fruit Vaccinium corymbosum extract for gallic acid estimation, Res J Life Sci Bioinform Pharm Chem Sci. 5:428-434.
  • Veeraraghavan, Pooja B, Hemavathi B S, Ramesh Kumar Kushwaha (2019), Tissue specific variation of stigma sterol content in Calotropis gigantean, Res J Life Sci Bioinform Pharm Chem Sci. 5:435-442.
  • Jayasri P, Jayalakshmi sinde, Kavya C M(2019), Secondary metabolites in Phyllanthusemblica fruit and their antioxidant property, Res J Life Sci Bioinform Pharm Chem Sci. 5:443-449.
  • H N Deepa, Varsha K S, Akhsa K Alexander, Jayashree S (2019), In Vitro study of the Anti-inflammatory activity of Quercetin from Murrayakoenigii leaf extract, Res J Life SciBioinform Pharm Chem Sci. 5:460-466.
  • Ramesh Kumar Kushwaha, Risha Das, Ankita Debnath, Budhaditya Dey (2019), Qualitative and quantitative aspect of various secondary metabolites present in Trigonella foenum- graecum leaves, Res J Life Sci Bioinform Pharm Chem Sci. 5:467-474.
  • Rakshit Jujare, Rishab Aditya, Rakesh Sarkar, JayashreeS (2019), Determination of Anti-bacterial Activity of Leucus aspera plant, Res J Life Sci Bioinform Pharm Chem Sci. 5:482-487.
  • Rijuta Ganesh Saratale, Ganesh Dattatraya Saratale, Si-Kyung Cho, Gajanan Ghodake, Avinash Kadam, Sunil Kumar, Sikandar I. Mulla, Dong-Su Kim, Byong-Hun Jeon, Jo Shu Chang, Han-Seung Shin (2019). Phyto-fabrication of silver nanoparticles by Acacia nilotica leaves: Investigating their antineoplastic, free radical scavenging potential and application in H2O2 sensing. Journal of the Taiwan Institute of Chemical Engineers, 99:239-249.
  • Gaurav Saxena, Diane Purchase, Sikandar I. Mulla, Ganesh D Saratale, Ram Naresh Bharagava (2019). Phytoremediation of heavy metal-contaminated sites: eco-environmental concerns, field studies, sustainability issues and future prospects. Reviews of Environmental Contamination and Toxicology, Online first,
  • Zabin K. Bagewadi, Uday M. Muddapur, Savita S. Madiwal, Sikandar I. Mulla, Aejaz Khan (2019). Biochemical and enzyme inhibitory attributes of methanolic leaf extract of Daturainoxia Mill. Environmental Sustainability, 2: 75-87.
  • Gulamnabi L. Vanti, Vijendra B. Nargund, Basavesha K. N, Rajinikanth Vanarchi, Mahantesh Kurjogi, Sikandar I. Mulla*, Suresh Tubaki, Rajashekar R. Patil (2019). Synthesis of Gossypiumhirsutum derived silver nanoparticles and its antibacterial efficacy against plant pathogens. Applied Organometallic Chemistry, 33: e4630.
  • Li Lu, Jiangwei Li, Anyi Hu, Sikandar I. Mulla, Jinyan Yang, Chang-Ping Yu (2019). Microbial community structure analysis and isolation of vanadium resistant strains in vanadium mining impacted soil. Journal of Soil and Water Conservation,74: 300-312.
  • JairoCaza, Rodolfo Fernández, Marbel Torres Arias, Daysi Muñoz, Juan Ortiz Tirado, Bangeppagari Manjunatha, Sikandar I. Mulla, Rajesh R Kundapur (2019). The Development, purification and characterization of anti- Vitellogenin antibodies raised in hens (Gallus gallusdomesticus) against Tilapia (Oreochromisniloticus) Vitellogenin protein. Journal of Microbiology, Biotechnology and Food Sciences,8: 1165-1168.
  • Samira Reinoso, Daysi Muñoz, Ricardo Cedeño, Juan Ortiz Tirado, Manjunatha Bangeppagari, Sikandar I. Mulla (2019). Adaptation of "Biofloc" aquatic system for polyculture with tilapia (Oreochromis sp.) and river prawn (Macrobrachiumsp.). Journal of Microbiology, Biotechnology and Food Sciences,8:1130-1134.
  • Dr.Jayashree.S, Ramesh N, Vinni Viridi, Shivaprasad, Vijayalakshmi K. (2012). Analysis of diabetic retinopathy biomarker VEGF gene by computational approaches, J. Biochem., Tech, 4 (1): 565-567.
  • Jayashree,S. Ramesh, N., Sumathi, C., Vijayalakshmi K. (2015). Quantification of Quercetin in Cyperus rotundus by HPTLC. Indo American Journal of Pharmaceutical Research, 5 (11): 3676-81
  • C.Sumathi1, S.Jayashree2 and G.Sekaran1(2011)Screening of antifungal activity of pink pigmented bacteria isolated from freshwater fish Labeo rohita Journal of Pharmacy Research 4(12)
  • Jayashree,S. Reena Rosy Thomas, K.Vijayalakshmi (2018)Identification of Bioactive compounds in Cyperus rotundus by GC-MS Analysis and their inhibitory effect in Diabetic complications through Docking. Indo American Journal of Pharmaceutical Research.3(10) 1516-21
  • Byre Gowda, G, Charanraj, T.P, Pradeepa Kumara, C.S, Ramesh, N. and Thomas, S.P. and Sadashiva, M.P. and Junjappa, H. Synthesis of novel β-aryl-β-(methylthio)acroleins via Vilsmeier–Haack protocol as potential 1,3-dielectrophilic three-carbon building blocks, (2014), Tetrahedron Letters, 55 (32). pp. 4475-4479. ISSN 0040-4039
  • T. P. Charanraj , P. Ramachandra , N. Ramesh , H. Junjappa, Fluorination of a-oxoketenedithioacetals: one-pot four-component synthesis of a-fluoro-a-oxoketenedithioacetals,Tetrahedron Lett., April 2016.
  • Synthesis of Hitherto Unknown 1,1,1,3-tetradeutero-4,4-bis(methylthio)-but-3-en-2-one and their Application for the Synthesis of Deuterated Aromatics and Heterocycles, Tetrahedron Lett.,2017
  • Gautama Reddy KV, Meher Master Moos, 2015. Insecta diversity, species richness and evenness of "Thenwalking mango tree". Species, 15(48), 19-23.
  • Gautama Reddy KV, Meher Master Moos, 2015. Insecta flora and their behaviour on "The walking mango tree". Species, 15(48), 24-34.
  • Gautama Reddy KV, Meher Master Moos, 2015. Insecta flora and their behaviour on "The walking mango tree". Species, 15(48), 24-34.
  • Gautama Reddy KV, Sunil Kumar Manna, Meher Master Moos, Ravi Prakash N, 2016.Comparative Evaluation of Anti-Inflammatory & Anti-Tumorigenic efficacy of "The Walking Mango Tree" Bark extracts. Medical Science, 20(79), 80-90.
  • Gautama Reddy KV, Sunil Kumar Manna, Meher Master Moos, Ravi Prakash N, 2016. Metabolite Fingerprinting of "The Walking Mango Tree" Bark Extracts by HPLC- UV/DAD, GC-MS, MALDI-TOF Mass Spectrometry. Discovery, 52(243), 488-498.
  • National Conference on Chemistry, Biotechnology and molecular biology-an interface 2011 Arun Kumar, Sivaprasad, Hrudaya Bhaskar, Jayashree , Sumathi, Sekaran Phylogenetic analysis of Bacterial communities.
  • At National conference on Recent advances in Health, Agriculture and Enviornmental Biotechnology.-2012. Dr.Jayashree.S, Ramesh N, Vinni Viridi, Shivaprasad, Vijayalakshmi K. Analysis of diabetic retinopathy biomarker VEGF gene by computational approaches
  • Presented at International Conference-November 2015 on Women Empowerment at Indian Institute of Science, Bangalore on "Prevalance of Diabetic Retinopathy in woman" Dr.Jayashree.S, Ramesh N, Bharath, Meghana,Vijayalakshmi K.
  • Presented at KSTA Conference 2018 Reaction of 4,4-Dimethoxy-2-butanone as 1,3-Dielectrophylic 3-Carbon Building Block: New Route for the Synthesis of Toluene, o-Xylene, Naphthalenesand Pyrimidines, T P Charanraj, P Ramachandra, N Ramesh, H Junjappa
  • Presented at KSTA Conference 2018 Genetic Diversity, Molecular and Biochemical Analysis for BLAST Resistance in Rice Lekhana . R , Sahana .C , Dr. Harini Kumar
  • Presented at KSTA Conference 2018 Effect of Sodium Monofluoride (Present in Toothpaste) on plants Cleuxine coracana & Trigenella foenum-graecum Deepa H N, Manikanta.N, Poornima.B.K
  • Presented at REVA Research Conclave 2018 Correlation Of Biochemical Parameters and their significance in bone disease Jayasri.P, Joshitha R, Navitha J C, Supritha R .
  • Presented at REVA Research Conclave 2018 Structural Elucidation and Physiochemical Characterisation of lenvatinib chloro[LTB-Cl] Deepa .H.N Lekhana.M.U1 and Muralidar
  • Presented at REVA Research Conclave 2018 Correlation Of biochemical parameters and their significance in Diabetic complications. Dr.Jayashree.S, .Mary Roopa.C1 , Javeriya Shafi1
  • Presented at REVA Research Conclave 2018 Invitro study of selected plants (Nigella Sativa, Lantana canara) on cancer cell line. (HCT 116, Hep G2) Meghana, M.V. Jayashree,S Chaithra ,C.Varsha.K.S.
  • Computational screening of natural products to dengue virus by targeting NS3 and NS5. Pooja,R. Karkera and RaviKumar,Y.S.
  • Invitro study of Cyperus rotundus tuber extract on Diabetic Retinopathy Jayashree,S ,Shalini .S,Likitha PM.

Thrust Areas of Research

Primary Research Areas includes:

  • Analysis of Bioactive compounds derived from plant/animal source.
  • Computational approaches on biological data.
  • Isolation, purification and preparation of the compounds through analytical techniques-HPLC.
  • Animal cell culture - Cytotoxicity studies.
  • Clinical investigation on Biochemical parameters in diabetic complications,bone disorders and cardiovascular disorders.
  • Synthesis of organic compounds.
Research and Innovation
Office of Research and Innovation,
REVA University, Rukmini Knowledge Park Kattigenahalli, Yelahanka,
Bangalore – 560 064
Karnataka, India
+91-80-6622 6622
+91 9448809443

Faculty/Research scholars pursuing research/Higher studies

  • Mr.T.P.Charan Raj –Thesis Submitted
  • Mr.Ramesh Kumar Kushwaha - Thesis will be Submitted shortly
  • Ms.Pooja R.Karkera
  • Mrs.H.N.Deepa

MOU with Industry/R&D organizations

  • Foundation for Revitalization of Local Health Traditions (FRLHT), ENVIS centre on medicinal plants,Bangalore-64.
  • Skanda Lifesciences Pvt. Ltd, Bangalore – 560 091.
  • Biopractices India Pvt. Ltd.
  • R Analytical Services.
  • Clini India

Organised Events-Workshops/Conferences/ Live Webinars/Seminars/Industrial Visits.

  • Intercollegiate Science fest “BIOQUIMICA” on 7th March 2018.
  • Organised two days Hands on experience in HPLC on 20th21st April 2018.
  • Recent trends in advanced Clinical Research by Dr. Pramila Kalra, Professor of Endocrinology, M.S Ramaiah Medical college and hospital Bangalore on 11th February 2017.
  • Advanced instrumentation usage in Clinical Research by Dr. E.Ilango, Founder CEO Evergreen Bio-solution on 11th February 2017.
  • Technologies that shaped Immunological discoveries by Dr.R Manjunath, Professor of Biochemistry, IISC Bangalore on 11th February 2017.
  • Advances in Plant and industrial Biochemistry by Dr.U.V.Babu, Head, R&D, Phytochemistry Division, Himalaya Drug Company on 16th, March 2017.
  • Applications of nano particles by Dr. K Kannabiran Professor Dept of Bioscience, VIT Vellore Tamil Nadu on 20th November 2017.
  • Bonding in Chemistry by Professor H. Junjappa, INSA Honorary scientist on 20th April 2017.
  • FDP on 10th Feb-11th Feb 2017 in association with Bangalore University Biochemistry Teachers Forum.
  • Conducted workshop on Computer Aided Drug Design (CADD) on May 19th and 20th 2017.
  • Industrial visit to CFTRI –a CSIR lab, Mysore on 12th Oct 2017.
  • Role of Medicinal plants" Dr.Badami 2016.
  • Development of vaccines against infectious diseases.-Dr.V.V.S. SuryaNarayana,Principal Scientist, IVRI,2015.
  • PCR workshop for M.Sc Biochemistry and Biotechnology students by Biocon private limited. 2015.
  • Carrer Prospective in abroad by US Embassy 2014.
  • Green chemistry by Nitesh,H. Mehta, Director of Newreka Green Synth Technologies Pvt. Ltd., Mumbai 2013.
  • Technology of water purification system-Stanley Thomas, Merck Millipore.2011
Live Webinars

Carrer Prospective in abroad by US Embassy.
Green chemistry by Nitesh,H. Mehta, Director of Newreka Green Synth Technoilogies Pvt. Ltd., Mumbai.

Report On Activities Of School Of Biochemistry

National Conference on “Computational World in Life Sciences”

The Department of Biochemistry and Biotechnology, School of applied sciences organised a one day national conference Themed “Computational World in Life Sciences” on 12th January 2019 at A.P.J. Abdul Kalam Seminar hall, REVA University. The inaugural function was presided by Dr. P.Shyama Raju, Honorable chancellor, REVA University. Dr. Shailesh Kumar Staff Scientist II, Bioinformatics Laboratory, National Institute of Plant Genome Research (NIPGR), New Delhi was the esteemed chief guest for the conference and the guest of honour was Dr. Mohit Mazumder, Scientific Manager, Section of Computational Biology & Chemistry, Excelera-National network of Health system, Hyderabad. The other Dignitaries included Dr. S.Y.Kulkarni, Vice Chancellor, REVA University; Dr. N Ramesh, Dean, Faculty of Science and Technology, REVA University and Dr. Beena G Associate Dean, REVA University. Around 120 students and Research Scholars from various institutions across the Country participated in the conference and exhibited their Research. The conference received 67 Abstracts out of which 56 are to be published in the special issue of Research Journal of Life Sciences, Bioinformatics, Pharmaceuticals and Chemical Science which is UGC indexed. The formal inauguration was followed by Lecture sessions.

The First expository talk was delivered by Dr. Shailesh Kumar on “Surge of Genomics data from Microbes to plants. This was followed by the Second Lecture on “The use of AI/ML and deep learning in HIT Identification phase of drug discovery” by Dr. Mohit Mazumder. 30 Participants delivered an oral presentation of their research work and 19 posters were presented. The feedback received from participants were very encouraging. Prizes were distributed to the awardees of oral presentation segregated into three different categories: internal students, external scholars and internal scholars and top three prizes for posters during the valedictory function

Guest Lecture on “Cancers in Women and its awareness”

On account of International Women’s Day, The Department of Biochemistry, School of Applied sciences organized a Guest Lecture on “Cancers in Women and its awareness”under Bioquimica forum on 7/03/19 at Library Seminar Hall, REVA University. Resource Person was Dr Ajay Rao P, Chief consultant Radiology oncologist, Cytecare Cancer Hospitals. Around 150 female studentsand Faculty members were a part of this Guest Lecture. The most common types of cancer in women were discussed and some of the misconceptions in the subject was clarified. In a nutshell, it was a very informative lecture that we received on this women’s day. In continuation to this, screening and mammogram test was organized for the female staff of our university in association with Cytecare cancer hospitals under Unnathi Women’s forum on 8th March 2019. Around 40 female staff underwent the screening process as a self-care for this women’s day.

HPLC Workshop

Two days workshop on "Hands on experience in HPLC" was organized by Biochemistry department from School of Chemical and Biological Sciences on 20th and 21st April 2018 for undergraduate, post graduate students, Research scholars of REVA University as well as students from different colleges/research centres includes Indian Academy, M S Ramaiah, Brindavan, Garden city college,Pragathi degree college ,Oxford degree college, Government arts and science College, G K V K ,EICL Ltd. with the total participants of 144. Dr. P Shyama Raju, Chancellor , REVA University presided the formal function.The guest of Honour for the program was Dr.U.V.Babu, Scientist Himalaya drug company. Vice Chancellor REVA University Dr.S.Y.Kulkarni gracing the occasion.

Inter collegiate Science Fest

BIOQUMICA 2018: Organized on 7th march 2018. Dr. P Shyama Raju , Chancellor, REVA University presided over the function. The chief guest Dr. Thuppil Venkatesh and Vice chancellor Dr. S. Y Kulkarni gracing the occasion. Students from REVA University Garden City college, M S Ramaiah College, Pragathi college, Vijayapura, M E S College, Govt. Science College, Kristu Jayanti College attended the fest with the total participants of 223.


Industrial Visit

An industrial visit To CFTRI Mysore was arranged on October 12th -2017 . Thirty two students of I SEM M.Sc Biochemistry visited the Molecular Biology and Biochemistry laboratories.

Seminar attended -9th Bengaluru India Nano

A Seminar was organized by Government of Karnataka, Department of Science and Technology at Hotel Lalit Ashok .Thirty two students of II SEM M.Sc Biochemistry attended the seminar on Nanotechnology

Seminar Organized

School of Biochemistry ,REVA University organized a seminar on on 23rd March 2018 .Dr.Arumugam Muruganandam Managing Director and CEO, Affigenix Biosolutions, presented a talk on Career Seminar and Career Talks. Sixty students of M.Sc Applied Science attended the seminar.

REVA Open Day

REVA open day was organized by REVA University on 27th and 28th April 2018 .M.Sc Biochemistry students presented the posters and gave a demonstration on purification of compounds by column chromatography.